Current Research Projects

Study ID Project Title Principal Investigator Co-Investigator(s) Summary
IRB201601699 Electrical Inhibition (EI): A Preliminary Study to Prevent the Uterine Contractions of Human Preterm Labor and Preterm Birth John C. Smulian Kathryn Patrick, Frederick Naftolin. Jeffrey Karsdon The purpose of this study is to determine and evaluate the effectiveness of a new method of preventing human preterm uterine contractions with an electrical pacemaker, electrical inhibition (EI). The primary outcome is EI associated changes in contraction frequency. We hypothesize that human preterm uterine contractions can be safely and objectively inhibited with a weak electrical current provided by an EI device, and that this this effect is related to the timing and length of EI exposure.
IRB201702519 Comparison of the oncologic outcomes between minimally-invasive versus open-approach ovarian cancer surgery S. Joel Cardenas-Goicoechea David S. Schweer Ovarian cancer is the most lethal gynecologic cancer. The surgical approach for gynecologic cancers has been evolving, and recent studies have suggested that a minimally-invasive approach to surgical intervention to ovarian cancer is as safe and effective as the traditional “open/laparotomy” approach. The aim of this study is to compare oncologic outcomes of open versus minimally-invasive surgical approach.
IRB201801133 Resident Educational Resources Survey Alice S. Rhoton-Vlasak Sonia Mehta, Gabriella De Paz The purpose of this study is to assess the current educational resources for in-service examinations, and then make suggestions for updates if needed. There are many more medical students watching lectures online, and using online study guides and question banks. They become accustomed to this method. The study will explore if this is the same for resident physicians, and if not, how we can make changes that are consistent with their developed learning styles.
IRB201802182 Outcomes associated with robotic radical hysterectomy versus open approach in early-stage cervical cancer at multi-institutional cancer centers S. Joel Cardenas-Goicoechea David S. Schweer Surgical approach for early cervical cancer includes open versus minimally invasive (MIS). MIS has benefits inherent to minimally invasive surgery with no difference in survival. However, at the 2018 SGO Meeting, a retrospective study and prospective trial were both presented with results that conflict with previous systematic and retrospective reviews.
The main objective of this study is to assess the oncologic outcomes with open vs robotic surgery.
IRB201702698 Evaluation of gynecological oncologic outcomes in the elderly and super-elderly population S. Joel Cardenas-Goicoechea Sara E. Kennedy, David S. Schweer, Massoud B. Shoraka The elderly and super-elderly often do not receive standard treatment secondary to their advanced age. The purpose of this study is to evaluate and compare oncologic outcomes in this patient population who are medically optimized for proper treatment for gynecological cancers.
IRB201803108 Assessing the effects of single gene nucleotide polymorphisms on preterm neonatal respiratory distress syndrome among a cohort of pregnant women exposed to betamethasone Robert S. Egerman Taylor N. Ham, Sarah J. Ripps, Kendra R. Sylvester Armstrong, Nicole T. Cacho Antenatal glucocorticoids administered to mothers at risk for preterm delivery reduces the frequency of neonatal respiratory distress syndrome (RDS) by 60% and is standard of care. Variances in maternal and fetal steroid metabolism modify the efficacy of this intervention. The objective of this study is to assess associations between maternal and fetal single nucleotide gene polymorphisms and the frequency of RDS after exposure to steroids. Validation of SNPs will help to identify non-responders.
IRB201801018 Comparison Study of Human Ovarian Tissue Cryopreservation Methods Alice S. Rhoton-Vlasak Gregory M. Christman, Joseph M. Kramer, S. Joel Cardenas-Goicoechea, Hadeer U. E. Metwally, Nash S. Moawad, Alessanda F. Nascimento The UF Cancer Center treats female cancer patients who often will receive chemotherapy, which, in the worst scenario, leads to menopause. Options to address fertility preservation include oocyte/embryo cryopreservation. A new option under development is whole ovarian tissue freezing. Two competing methods have been examined. No research has compared the relative effectiveness of each method. This study plans to directly compare the methods of slow freezing to vitrification of tissue samples from the same human ovary.
IRB201900385 Fetal Sex Discordance Identification Following Non-Invasive Prenatal Testing: A Case Series Reem S. Abu-Rustum Massoud B. Shoraka, Kendra R. Sylvester-Armstrong, Sonja A. Rasmussen With the increasing availability of non-invasive prenatal testing (NIPT) and ultrasound, more cases of sex discordance are being identified in routine clinical practice. Knowledge about the limitations of NIPT and reasons for discordant results are fundamental. The purpose of this case series is to review cases from a single center and identify other possible limitations of NIPT in correctly identifying fetal sex chromosomes.
IRB201900213 Status of Ultrasound Education at UF’s Ob/Gyn Residency Program Reem S. Abu-Rustum Sharon Y. Byun, Robert S. Egerman, Jordan R. Preiss, Dikea Roussos-Ross Sonographic skill is critical for the obstetrician/gynecologist, as it directly impacts the quality of patient care. The purpose of this survey is to: evaluate the quality of ultrasound training at UF’s Ob/Gyn residency program (in Gainesville), identify the areas in need of improvement, and assess the residents’ subjective evaluation of their sonographic capabilities. Ultimately, we will use the data to establish a standardized ultrasound curriculum for our residency program.
IRB201900763 Determining narcotic use after enhanced recovery after surgery (ERAS) implementation in gynecologic oncology at the University of Florida S. Joel Cardenas-Goicoechea Elizabeth Plasencia It is well known that abdomino-pelvic surgery results in significant surgical stress. The Enhanced Recovery After Surgery (ERAS) program was created to provide a standard approach to pre- and post-operative care in order to decrease recovery time, requirement of pain medication, surgical complications, length of stay, and readmission rates. The goal of this study is to determine change in these outcomes at UF Health since ERAS protocol implementation.
IRB201900320 Evaluating efficacy of preoperative and operative antibiotic prophylaxis in gynecologic oncology patients Jacqueline C. Castagno Krisitn E. Briscoe It has been well established that preoperative administration of antibiotics reduces the rate of surgical site infection. In gynecologic oncology cases, cefoxitin or cefotetan are often used. This study is a retrospective evaluation of gynecologic oncology patients to assess the efficacy of antibiotics used. Medical comorbidities, operative time, operative complications, and operative techniques will also be reviewed.
IRB201900879 Assessment of Baseline Nutritional Habits, Needs, and Goals for Improved Nutrition and Achieving Recommended Weight Gain In Pregnancy Sharon Y. Byun Ana C. Mendia, Samantha A. Larson This study aims to gather information on our patients’ current nutritional habits and create educational support systems to provide patients with nutritional information that will help them improve their overall health and maintain weight gain in keeping with what is recommended by the Institute of Medicine.