Daniel Gibson, PhD

Dr. Daniel J. Gibson, PhD, Research Assistant Professor of OB/GYN

Dr. Gibson’s research focuses on combining his backgrounds in imaging, mechanical engineering, and biochemistry to improve wound healing research and the eventual translation of those findings into improved clinical outcomes for patients.  Dr. Gibson studies the cellular and molecular time lines of wound healing, synthesizing principles from biochemistry and engineering control systems to understand the roles and timing of cells, growth factors, and the matrix have on wound healing outcomes.  In particular, he is now studying the events which lead healing wounds to stall and become chronic wounds, and what causes surgical wounds on the corneas to heal via either regenerative healing or to become vision impairing scars.  Therapeutically, his wound healing research focuses on improving the knowledge of the timing and location of key cellular actors, and their molecular pathways, to be measured by his patented rapid, point-of-care (POC) detector system, and to be targeted by his now patented non-viral drug delivery system.

Dr. Gibson’s current research into why wounds transition into chronicity is centered on identifying the molecular status of chronic wounds.  Previous data from clinical trials supported by The Institute for Wound Healing Research showed that elevated level of matrix metalloproteinases (MMPs) in chronic wound fluids increased one week prior to the wound stalling.  This measurement, put into the hands of clinicians via a now patented technology, can predict periods of stalled healing and given clinicians insight to which patients need additional attention to get them back on a healing track.  What is also particularly exciting is that these same MMPs have been linked to other problems including chronic ocular surface disease (aka chronic dry eye syndrome), in pre-pre-mature rupture of membranes (pPROM), as well as many other chronic inflammatory diseases in a variety of tissues.  These detectors are now covered by 3 issued patents and 2 patent applications, and the platform is being prepared for expansion into measuring other biomarkers which may indicate other non-observable signs of clinical pathology.

Dr. Gibson’s research into point-of-care diagnostics and indicators includes a robust research program surrounding the use of non-invasive or minimally invasive imaging procedures and advanced image analysis approaches.  This research has included: the development and improvement of monitoring the progression of formation and maturation of corneal haze following laser surgery.  This work has formed the foundation for several external grants for pharmaceutical testing to improve post photorefractive keratectomy (PRK) surgical outcomes, and has led to novel discoveries about the manner in which the corneal scar forms.  Additionally, Dr. Gibson was awarded a matching funds grant from the Florida High Tech Corridor in collaboration with faculty from the department of Mechanical and Aerospace Engineering to support the translation and clinical testing of retinal fundus image analysis via novel fluid mechanics-based approaches and via a novel Voronoi analysis to determine the current degree that the retina is served by the vasculature, and how it changes during disease progression.

Dr. Gibson’s third area of focus is on the field of biomechanics of wound healing devices.  To date, the research has included testing and identifying  the fluid mechanical principles  of negative pressure wound therapy (NPWT) in order to test and guide refinement of  NPWT dressings.  Additionally, the material mechanics and microfluidic mechanics of dressings designed to support and protect patients skin in areas sensitive to the formation of bed sores.

In addition to his own research, Dr. Gibson provides mentoring and other research support for research in Veterinary Ophthalmology and is expanding his collaborative research into the biomechanics of pelvic floor organ prolapse and addressing the current short-comings of current clinical interventions.

Finally, Dr. Gibson has very active interest in translational research and considers himself a translational research/entrepreneurship evangelist.

 

Publications:

  1. Antibacterial and Flow Rate Assessment of a Nonadherent Layer Interface on a Silver Alginate Dressing.” Yang Q; Kerekes, DT; Schultz, G; Gibson DJ. WOUNDS. 2015;27(1):1-4.
  2. Medical Honey and Silver Dressings Do Not Interfere with Each Other’s Key Functional Attributes.” Gibson DJ; Yang Q; Kerekes, DT; Schultz, GS. WOUNDS. 2014;26(11):309-316..
  3. Assessment of Anti-Scarring Therapies in Ex Vivo Organ Cultured Rabbit Corneas.” Sriram S, Gibson DJ, Robinson P, Pi L, Tuli SS; Lewin AS, Schultz GS.   2014 Aug;125.
  4. Conditional Knockout of CTGF Affects Visual Function and Corneal Wound Healing.Gibson DJ, PI L, Sriram S, Mao C, Petersen BE, Scott EW, Leask AW, and Schultz GS. Invest Ophthalmol Vis Sci, April 2014 55:2062-2070. (Cover Image).
  5. “The Progression of Haze Formation in Rabbit Corneas Following Phototherapeutic Keratectomy.” Gibson DJ, Tuli SS, and Schultz GS. Invest Ophthalmol Vis Sci. 2013 July 16, 2013 54(7) 4776-4781.
  6. “Molecular Wound Assessments: Matrix Metalloproteinases.” Daniel J. Gibson and Gregory S. Schultz. Advances in Wound Care. January/February 2013, 2(1): 18-23.
  7. “Ectopic Epithelial Implants Following Surface Ablation of the Cornea.” Gibson DJ and Schultz GS. Invest Ophthalmol Vis Sci. 2012 Nov 21;53(12):7760-5. doi: 10.1167/iovs.12-10768. PMID: 23132801.
  8. “A Connective Tissue Growth Factor Signaling Receptor in Corneal Fibroblasts.” Blalock TD, Gibson DJ, Duncan MR, Tuli SS, Grotendorst GR, Schultz GS. A Connective Tissue Growth Factor Signaling Receptor in Corneal Fibroblasts. Invest Ophthalmol Vis Sci. 2012 Jun 5;53(7):3387-94. doi: 10.1167/iovs.12-9425. Print 2012 Jun.
  9. “Vorinostat: A potent agent to treat laser-induced corneal haze.”
    Tandon A, Tovey JCK, Waggoner MR, Sharma A, Cowden JW, Gibson DJ, Liu Y, Schultz GS, Mohan RR. Vorinostat: A potent agent to treat laser-induced corneal haze. Journal of Refractive Surgery.
  10. “MMP’s Made Easy”
    Gibson DJ
    , Cullen B, Legerstee R, Harding KG, Schultz G. MMPs made easy. Wounds International. 2009; 1(1). Available from: http://www.woundsinternational.com/pdf/content_21.pdf (Last Accessed: 9 Dec 2010)
  11. “Chronic wound diagnostic for matrix metalloproteinase”
    Gibson DJ, Schultz GS. Chronic wound diagnostic for matrix metalloproteinase. Wound Heal Southern Africa. 2010;2(2):58-70. Available from: http://www.woundhealingsa.co.za/index.php/WHSA/article/view/51/0 (Last Accessed: 9 Dec 2010)
  12. “Assessing the bioburden in poorly healing wounds”
    Phillips P, Yang Q, Gibson D, Schultz G. Assessing the bioburden in poorly healing wounds. Wounds International. 2011; 2(2).

Published Book Chapters

  1. J. Gibson and G.S. Schultz. A Corneal Scarring Model. Wound Repair and Regeneration: Methods and Protocols. Humana Press. (In Press).
  2. J. Gibson and G.S. Schultz. Molecular Wound Assessments: Matrix Metalloproteinases. In: Wound Healing Society Year Book (WHSYB)- Advances in Wound Care, vol. 3, Mary Ann Liebert, Inc., New Rochelle, NY.
  3. S. Schultz and D.J. Gibson. Measurement of Biomarkers for Impaired Healing in Fluids and Tissues.  In: Measurements in Wound Healing: Science and Management, R. Mani and V. Shukla eds, Springer Publishing Co, New York, NY, in press.