Dr. Gregory Schultz, PhD, Professor of OB/GYN

Dr. Schultz's research focuses on the molecular regulation of wound healing, and the imbalances that lead to chronic wounds or hypertrophic scars. His antiscarring research focuses on using antisense oligonucleotides and AAV-vectored ribozymes and siRNAs targeting mRNAs for transforming growth factor beta (TGFb) and connective tissue growth factor (CTGF), which are the two most important growth factor systems that regulate scarring. Target tissues include skin, cornea and peritoneal adhesions. Dr. Schultz' research on chronic wounds has shown that the major cause for non-healing is the presence of bacterial biofilms that stimulate chronic inflammation and lead to chronically elevated proteases that degrade proteins that are essential for healing. He currently is conducting clinical trials on a rapid point-of-care detector for proteases in wound fluids combined with topical treatments that inhibit proteases (doxycycline) and patented bacterial barrier dressings with a unique non-leaching microbicidal polymer.

• Current Research
• Publications