3rd year Fellow: Jessica R. Jackson, MD, MS
Mentor: Martha Campbell-Thompson, Ph.D.
University of Florida, College of Medicine, Department of Pathology, Immunology, and Laboratory Medicine
Peripheral Immune Defects in Preeclampsia
Immunologic role of t regulatory cells in preeclampsia
2nd year Fellow: Kathryn E. Patrick, MD
Mentor: Clive Wasserfall, MSC, University of Florida Diabetes Institute and Anthony R. Gregg, M.D., MBA, University of Florida College of Medicine, Department of Obstetrics and Gynecology
Hypothesis: Electrical Inhibition (EI) A preliminary study to prevent uterine contractions associated with preterm labor and preterm birth.
Brief Description: Transplacental glucose transfer is the primary means of delivering glucose from mother to fetus during pregnancy and is mediated by the facilitative glucose transporter, GLUT-1. Little is known about the regulation of GLUT-1 by cytokines. Adipocytokines (i.e. TNF-alpha, IL-6, leptin) have been implicated in the pathophysiology of obesity and diabetes. It is hypothesized that adipocytokines alter human placental GLUT-1 expression potentially leading to abnormal fetal growth and metabolism